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. 2019 Dec 24;2019:7252013. doi: 10.1155/2019/7252013

Figure 3.

Figure 3

The main targets of miR-221/222 involved in liver cancer. miR-222 is a tumor suppressor by inhibiting PBX3 expression, which activates the α2δ1 expression. α2δ1 is a surface marker that marks HCC tumor initiating cells (TICs). However, miR-221/222 is often used as an onco-miRNA in liver cancer cells. BBC3, GNAI3, and PPP2R2A have been identified as a target for miR-222 and p57. DDIT4, BMF, HDAC6, AdioR1, and ERα have been identified as a target for miR-221. PTEN, TIMP3, and p27/CDKN1B have been identified as a target for miR-221/222. The downregulation of these targets promotes liver cell proliferation, invasion, and metastasis.