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. 2019 Dec 24;2019:7252013. doi: 10.1155/2019/7252013

Figure 4.

Figure 4

The main targets of miR-221/222 involved in colorectal cancer. miR-222 directly targets ADAM-17, which was downregulated in multidrug-resistant CRC cells and increase cancer cells' apoptosis. Meanwhile, miR-221/222 is an onco-miRNA in colorectal cancer cells. MST3 and MIA3 have been identified as a target for miR-222. RECK and TP53INP1 have been identified as a target for miR-221. p27/CDKN1B, p57/CDKN1C, and PTEN have been identified as a target for miR-221/222. The downregulation of these targets promotes colorectal cell proliferation, invasion, and metastasis.