Table 2.
Biochemical parameters of rats after treatment with repeated oral doses of Minthostachys mollis essential oil (Mm-EO) for 28 days.
| Parameters | Control | Mm-EO 100 | Mm-EO 250 | Mm-EO 500 |
|---|---|---|---|---|
| Males | ||||
| AST (IU/L) | 144.33 ± 6.81 | 161.67 ± 9.07 | 171.33 ± 11.37∗ | n.d. |
| ALT (IU/L) | 61.67 ± 13.61 | 80.33 ± 10.02 | 99.00 ± 11.53∗ | n.d. |
| Alkaline phosphatase (IU/L) | 175.67 ± 9.29 | 176.33 ± 4.04 | 181.00 ± 11.53 | n.d. |
| Total bilirubin (mg/dL) | 0.61 ± 0.13 | 0.62 ± 0.07 | 0.65 ± 0.06 | n.d. |
| Total protein (g/dL) | 7.23 ± 0.61 | 7.33 ± 0.61 | 7.53 ± 0.32 | n.d. |
| Albumin (g/dL) | 3.70 ± 0.36 | 3.90 ± 0.26 | 3.83 ± 0.49 | n.d. |
| Cholesterol (mg/dL) | 69.83 ± 4.25 | 65.40 ± 9.18 | 50.67 ± 8.33∗ | n.d. |
| Triglycerides (mg/dL) | 102.00 ± 11.79 | 79.33 ± 13.01 | 41.00 ± 8.89∗ | n.d. |
| HDL (mg/dL) | 30.77 ± 4.68 | 34.00 ± 5.14 | 35.13 ± 3.56 | n.d. |
| LDL (mg/dL) | 18.66 ± 2.55 | 15.53 ± 3.22 | 7.34 ± 2.19∗ | n.d. |
| Glucose (mg/dL) | 116.10 ± 8.65 | 108.43 ± 11.76 | 112.17 ± 7.52 | n.d. |
| Urea (mg/dL) | 34.00 ± 4.36 | 33.50 ± 3.12 | 29.83 ± 1.61 | n.d. |
| Creatinine (mg/dL) | 0.94 ± 0.08 | 0.85 ± 0.08 | 0.65 ± 0.04∗ | n.d. |
|
| ||||
| Females | ||||
| AST (IU/L) | 130.33 ± 5.50 | 144.33 ± 15.63 | 155.67 ± 12.89 | 168.33 ± 5.51∗ |
| ALT (IU/L) | 58.67 ± 9.71 | 83.67 ± 18.50 | 101.33 ± 11.37∗ | 109.00 ± 6.56∗ |
| Alkaline phosphatase (IU/L) | 174.00 ± 9.64 | 178.67 ± 17.61 | 177.67 ± 14.19 | 179.33 ± 6.03 |
| Total bilirubin (mg/dL) | 0.62 ± 0.14 | 0.62 ± 0.11 | 0.63 ± 0.15 | 0.66 ± 0.05 |
| Total protein (g/dL) | 7.23 ± 0.66 | 7.50 ± 0.36 | 7.20 ± 0.65 | 7.37 ± 0.49 |
| Albumin (g/dL) | 3.80 ± 0.20 | 3.73 ± 0.35 | 3.67 ± 0.31 | 3.65 ± 0.04 |
| Cholesterol (mg/dL) | 78.40 ± 10.05 | 58.00 ± 5.07∗ | 45.27 ± 5.00∗ | 42.90 ± 3.73∗ |
| Triglycerides (mg/dL) | 95.27 ± 11.08 | 82.03 ± 4.21 | 31.33 ± 3.21∗ | 30.13 ± 2.80∗ |
| HDL (mg/dL) | 33.13 ± 4.27 | 34.00 ± 5.60 | 34.03 ± 4.59 | 32.43 ± 2.89 |
| LDL (mg/dL) | 26.22 ± 5.15 | 7.59 ± 2.27∗ | 4.97 ± 0.73∗ | 4.44 ± 1.02∗ |
| Glucose (mg/dL) | 119.23 ± 6.49 | 113.23 ± 9.87 | 110.27 ± 14.14 | 115.07 ± 3.58 |
| Urea (mg/dL) | 35.97 ± 2.34 | 31.53 ± 2.84 | 28.47 ± 4.05 | 32.53 ± 5.06 |
| Creatinine (mg/dL) | 0.91 ± 0.08 | 0.82 ± 0.07 | 0.63 ± 0.06∗ | 0.60 ± 0.04∗ |
Values are expressed as Mean ± SD, significance when compared with control ∗(p < 0.05). One-way ANOVA followed by Tukey test. AST, Aspartate aminotransferase; ALT, alanine aminotransferase; ALP, alkaline phosphatase; HDL, high-density lipoprotein; LDL, low-density lipoprotein. n.d., not determined because rats died in the first week of treatment.