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Forest plot of subgroup meta-analysis of the rates of disease progression at 1 year. (a) Subgroup analyses of intrathecal injection versus intravenous injection. (b) Subgroup analyses of baseline EDSS ≤ 6.5 versus baseline EDSS > 6.5. (c) Subgroup analyses of baseline age ≤ 44 y versus baseline age > 44 y. (d) Subgroup analyses of MS duration ≤ 15 y versus MS duration > 15 y. Squares indicate the risk ratio, and horizontal lines represent 95% confidence intervals.
