Table 1.
Characteristics of homozygotes in kindreds with severe high-density lipoprotein deficiency
Approximate laboratory values | ApoA-I deficiency | Tangier disease | LCAT deficiency* |
---|---|---|---|
Total cholesterol (mg/dL) | 150 | 90 | 110 |
Triglyceride (mg/dL) | 80 | 180 | 200 |
HDL-C (mg/dL) | 2 | 3 | 9 |
LDL-C (mg/dL) | 130 | 60 | 65 |
ApoA-I (mg/dL) | 0 | 4 | 35 |
Clinical findings | |||
Xanthomas | Can have planar or tubero-eruptive | Negative | Negative |
Corneal opacification | Mild–moderate | Very mild | Striking |
Coronary heart disease risk | +++ | + | ? |