Skip to main content
. Author manuscript; available in PMC: 2020 Jan 5.
Published in final edited form as: J Clin Lipidol. 2008 Jun 13;2(4):237–247. doi: 10.1016/j.jacl.2008.06.002

Table 1.

Characteristics of homozygotes in kindreds with severe high-density lipoprotein deficiency

Approximate laboratory values ApoA-I deficiency Tangier disease LCAT deficiency*
Total cholesterol (mg/dL) 150 90 110
Triglyceride (mg/dL) 80 180 200
HDL-C (mg/dL) 2 3 9
LDL-C (mg/dL) 130 60 65
ApoA-I (mg/dL) 0 4 35
Clinical findings
 Xanthomas Can have planar or tubero-eruptive Negative Negative
 Corneal opacification Mild–moderate Very mild Striking
 Coronary heart disease risk +++ + ?

Apo, apolipoprotein; HDL-C, high-density lipoprotein cholesterol; LCAT, lecithin:cholesterol acyl transferase; LDL-C, low-density lipoprotein cholesterol.

*

Increased risk of developing renal failure, see references 31, 37, and 48.

HHS Vulnerability Disclosure