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. Author manuscript; available in PMC: 2020 Jan 5.
Published in final edited form as: J Clin Lipidol. 2008 Jun 13;2(4):237–247. doi: 10.1016/j.jacl.2008.06.002

Table 2.

Characteristics of homozygotes with marked high-density lipoprotein deficiency and undetectable plasma apolipoprotein A-I levels

Disorder ApoA-I deficiency ApoA-I/C-III deficiency ApoA-I/C-III/A-IV deficiency*
Triglyceride Normal Decreased Decreased
LDL-C Normal Normal Normal
HDL-C <5 mg/dL <5 mg/dL <5 mg/dL
ApoA-I Undetectable Undetectable Undetectable
ApoC-III Present Undetectable Undetectable
ApoA-IV Present Present Undetectable
Planar xanthomas Positive Positive Negative
Tubero-eruptive xanthomas Positive Negative Negative
Premature CHD Positive Positive Positive

Apo, apolipoprotein; CHD, coronary heart disease; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol.

*

Evidence of fat malabsorption, see references 1732, especially 17–21, 26, and 31.

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