Table 2.
Characteristics of homozygotes with marked high-density lipoprotein deficiency and undetectable plasma apolipoprotein A-I levels
Disorder | ApoA-I deficiency | ApoA-I/C-III deficiency | ApoA-I/C-III/A-IV deficiency* |
---|---|---|---|
Triglyceride | Normal | Decreased | Decreased |
LDL-C | Normal | Normal | Normal |
HDL-C | <5 mg/dL | <5 mg/dL | <5 mg/dL |
ApoA-I | Undetectable | Undetectable | Undetectable |
ApoC-III | Present | Undetectable | Undetectable |
ApoA-IV | Present | Present | Undetectable |
Planar xanthomas | Positive | Positive | Negative |
Tubero-eruptive xanthomas | Positive | Negative | Negative |
Premature CHD | Positive | Positive | Positive |