Table 3.
Characteristics of homozygotes with marked high-density lipoprotein deficiency and detectable plasma apolipoprotein A-I levels
Disorder | Tangier disease* | Partial LCAT deficiency (fish-eye disease)* | LCAT deficiency* |
---|---|---|---|
Triglyceride | Increased | 50% increased | 50% increased |
LDL-C | Decreased | 50% of normal | Decreased |
HDL-C | <5 mg/dL | 10% of normal | <5 mg/dL |
ApoA-I | <10 mg/dL | 20% of normal | <40 mg/dL |
ApoC-III | Present | Present | Present |
ApoA-IV | Present | Present | Present |
Xanthomas | Negative | Negative | Negative |
Corneal opacification | Mild | Positive | Positive |
Premature CHD | Positive | Not striking | Not striking |
Apo, apolipoprotein; CHD, coronary heart disease; HDL-C, high-density lipoprotein cholesterol; LCAT, lecithin:cholesterol acyl transferase; LDL-C, low-density lipoprotein cholesterol.