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. Author manuscript; available in PMC: 2020 Jan 5.
Published in final edited form as: J Clin Lipidol. 2008 Jun 13;2(4):237–247. doi: 10.1016/j.jacl.2008.06.002

Table 3.

Characteristics of homozygotes with marked high-density lipoprotein deficiency and detectable plasma apolipoprotein A-I levels

Disorder Tangier disease* Partial LCAT deficiency (fish-eye disease)* LCAT deficiency*
Triglyceride Increased 50% increased 50% increased
LDL-C Decreased 50% of normal Decreased
HDL-C <5 mg/dL 10% of normal <5 mg/dL
ApoA-I <10 mg/dL 20% of normal <40 mg/dL
ApoC-III Present Present Present
ApoA-IV Present Present Present
Xanthomas Negative Negative Negative
Corneal opacification Mild Positive Positive
Premature CHD Positive Not striking Not striking

Apo, apolipoprotein; CHD, coronary heart disease; HDL-C, high-density lipoprotein cholesterol; LCAT, lecithin:cholesterol acyl transferase; LDL-C, low-density lipoprotein cholesterol.

*

In Tangier disease only pre–β-1 ApoA-I– containing HDL are present, whereas in LCAT deficiency, pre–β-1 and α-4 HDL particles are present (see references 37, 38, and 48, and Fig. 5).

HHS Vulnerability Disclosure