3.
Diagnostic performance of the 4 tests for discrimination of different subtypes of ovarian mass stratified by menopausal status
| Group | Tests | AUC(95%CI) | SN(% | SP(%) | PPV(%) | NPV(%) |
| OC+BOT (n=188) vs Benign (n=531) | ||||||
| CA125 | 0.729 (0.670, 0.789) | 60 | 72.3 | 30.3 | 90.0 | |
| Premenopausal | HE4 | 0.766 (0.705, 0.828) | 46.3 | 93.9 | 60.3 | 89.7 |
| ROMA | 0.771 (0.710, 0.832) | 56.8 | 88.2 | 49.1 | 91.0 | |
| CPH-I | 0.778 (0.721, 0.835) | 46.3 | 96.0 | 69.8 | 89.9 | |
| CA125 | 0.870 (0.813, 0.928) | 80.6 | 77.6 | 85.2 | 71.4 | |
| Postmenopausal | HE4 | 0.912 (0.867, 0.958) | 67.7 | 98.3 | 98.4 | 65.5 |
| ROMA | 0.903 (0.855, 0.950) | 81.7 | 82.8 | 88.4 | 73.8 | |
| CPH-I | 0.904 (0.856, 0.951) | 81.7 | 84.5 | 89.4 | 74.2 | |
| EOC (n=119) vs Benign (n=531) | ||||||
| CA125 | 0.836 (0.757, 0.915) | 75.6 | 72.3 | 20.6 | 96.9 | |
| Premenopausal | HE4 | 0.895 (0.825, 0.965) | 75.6 | 93.9 | 54.0 | 97.6 |
| ROMA | 0.898 (0.829, 0.968) | 80.0 | 88.2 | 39.1 | 97.9 | |
| CPH-I | 0.898 (0.835, 0.962) | 73.3 | 96.0 | 63.5 | 97.4 | |
| CA125 | 0.924 (0.877, 0.972) | 89.2 | 77.6 | 83.5 | 84.9 | |
| Postmenopausal | HE4 | 0.956 (0.922, 0.990) | 82.4 | 98.3 | 98.4 | 81.4 |
| ROMA | 0.955 (0.919, 0.991) | 91.9 | 82.8 | 87.2 | 88.9 | |
| CPH-I | 0.953 (0.917, 0.989) | 91.9 | 84.5 | 88.3 | 89.1 | |
| EOC (n=119) vs Non-EOC+BOT (n=69) | ||||||
| CA125 | 0.768 (0.666, 0.871) | 75.6 | 54.0 | 59.6 | 71.1 | |
| Premenopausal | HE4 | 0.826 (0.737, 0.915) | 75.6 | 80.0 | 77.3 | 78.4 |
| ROMA | 0.827 (0.738, 0.916) | 80.0 | 64.0 | 66.7 | 78 | |
| CPH-I | 0.828 (0.740, 0.916) | 73.3 | 78.0 | 75.0 | 76.5 | |
| CA125 | 0.886 (0.816, 0.956) | 89.2 | 52.6 | 88.0 | 55.6 | |
| Postmenopausal | HE4 | 0.915 (0.858, 0.972) | 82.4 | 89.5 | 96.8 | 56.7 |
| ROMA | 0.922 (0.869, 0.976) | 91.9 | 57.9 | 89.5 | 64.7 | |
| CPH-I | 0.917 (0.861, 0.973) | 91.9 | 57.9 | 89.5 | 64.7 | |