METTL14 mRNA expression in human liver disease from microarray datasets. (A) Boxplots showing METTL14 mRNA expression in normal liver and HCC. *, P<0.05; ***, P<0.001, paired t-test; (B) METTL14 mRNA expression in normal liver and cirrhotic liver. *, P<0.05; **, P<0.01, unpaired t-test; (C,D) METTL14 mRNA expression in patients with various stages of liver disease leading to HCC. Statistical analysis was performed using one-way ANOVA comparing the mean of each column to normal liver and the posttest for the linear trend. n.s., no significance; T, tumor; N, normal; v., versus; CS, cirrhosis; DN, dysplastic nodules; HCC, hepatocellular carcinoma; CH, chronic hepatitis.