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Relationship between OPN level and tumor volume. (A) Correlation between serum OPN and tumor volume (n=124, r=0.353, P<0.001); (B) correlation between tissue SPP1-mRNA and tumor volume (n=85, r=−0.247, P=0.023); (C) correlation between tissue OPN and tumor volume (n=228, P=0.960); (D) correlation between circulating OPN/volume and local SPP1-mRNA (n=41, r=0.346, P=0.027). OPN, osteopontin.
