Table S1. Association between clinicopathological features and OPN expression level in ICC tissues.
| Variable | OPN expression subgroup | P value | ||
|---|---|---|---|---|
| Low | Medium | High | ||
| ALL cases | 63 | 140 | 25 | |
| Gender, male vs. female | 37:26 | 88:52 | 10:15 | 0.101 |
| Age, years, ≥60 vs. <60 | 26:37 | 60:80 | 14:11 | 0.424 |
| Multiple tumors, present vs. absent | 17:46 | 32:108 | 6:19 | 0.818 |
| Tumor size, cm, >5 vs. ≤5 | 38:25 | 83:57 | 15:10 | 0.990 |
| Tumor capsule, incomplete vs. complete | 58:5 | 122:18 | 22:3 | 0.593 |
| Vascular invasion, present vs. absent | 7:56 | 26:114 | 3:22 | 0.348 |
| Lymph node metastasis, present vs. absent | 17:46 | 23:117 | 1:24 | 0.031* |
| Edmondson’s grade, III-IV vs. I-II | 26:37 | 63:78 | 3:22 | 0.008* |
| Liver cirrhosis, with vs. without | 13:50 | 37:103 | 5:20 | 0.591 |
| HBsAg, positive vs. negative | 22:41 | 56:84 | 11:14 | 0.684 |
| Serum bilirubin, μmol/L, >20.4 vs. ≤20.4 | 8:49 | 7:124 | 2:21 | 0.131 |
| Serum albumin, g/L, <35 vs. ≥35 | 3:52 | 5:114 | 2:18 | 0.551 |
| ALT, U/L, >50 vs. ≤50 | 12:45 | 34:97 | 2:21 | 0.179 |
| γ-GT, U/L, >60 vs. ≤60 | 28:29 | 59:72 | 7:16 | 0.309 |
| AFP, ug/L, >20 vs. ≤20 | 7:56 | 18:122 | 2:23 | 0.770 |
| CEA, ng/mL, >5 vs. ≤5 | 8:31 | 20:78 | 1:18 | 0.281 |
| CA19-9, U/mL, >37 vs. ≤37 | 38:25 | 70:70 | 10:15 | 0.183 |
| TNM stage, III-IVA vs. I-II | 20:43 | 30:110 | 2:23 | 0.102 |
Data are expressed as ratios. *, P<0.05 by the Kruskal-Wallis test. HBsAg, hepatitis B surface antigen; TB, total bilirubin; ALB, albumin; ALT, alanine aminotransferase; γ-GT, γ-glutamyl-transferase; AFP, alpha-fetoprotein; CEA, carcinoembryonic antigen; CA19-9, carbohydrate antigen 19-9; OPN, osteopontin; ICC, intrahepatic cholangiocarcinoma.