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. 2019 Sep 26;48(D1):D383–D388. doi: 10.1093/nar/gkz827

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Searching Thera-SAbDab. (A) Search by attribute. Here, we search for any therapeutic designed to bind to ERBB2 (often over-expressed in breast cancer). (B) Eight therapeutics are designed to bind to ERBB2, seven monoclonals and one bispecific. Four have exact structural information for the ERBB2 binding site. Click the therapeutic name to enter the therapeutic summary page. (C) Search by sequence. Here we search for therapeutics with at least 70% sequence identity across the heavy and light chain CDRs of the input sequence. (D) Any results are returned alongside sequence identity across the specified region. Alignments show any sequence mismatches across the variable domain sequence.

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