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. 2019 Oct 10;48(D1):D204–D219. doi: 10.1093/nar/gkz869

Figure 4.

Figure 4.

In-house denovo Parkinson disease (DeNoPa). (A) sRNA DE Overlap. Overlap of upregulated sRNAs between in-house denopa (blue), AD (purple) and HD (orange). Overall nine neurodegenerative disease comparisons were considered and overlap was found with these two datasets. (B) GO terms. Top 10 GO terms associated with the target genes of the two downregulated sRNAs. (C) sRNA classification Overlap. Overlap of classification features (sRNAs) between in-house denopa (blue), AD (two datasets) (purple) and HD (orange). (D) DeNoPa classification. Receiver‐operating characteristic (ROC) curve showing true‐ and false‐positive rates for DeNoPa disease prediction based on sRNA expression profile using 18 sRNAs in full model (blue) and 16 unique (not found in other neurodegenerative diseases) sRNAs (red). (E) PD associated genes. Network of PD associated genes and 13 known miRNAs from the classification. (F) GO terms for novel miRNAs. GO terms associated with the target genes of the three novel miRNAs from the classification.