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. 2019 Nov 22;48(1):16–35. doi: 10.1093/nar/gkz1101

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© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Mitochondrial localization and TRAF6-mediated nuclear translocation of human DNA2. Like its yeast counterpart, human DNA2 migrates into both mitochondria and nuclei. However, unlike scDNA2, human DNA2 has no NLS and translocates into nuclei via an NLS-independent mechanism that depends on TRAF6-mediated polyubiquitination. Once in the nucleus, DNA2 can localize to telomeres, centromeres or the nucleolus to facilitate the DNA replication of these difficult-to-replicate regions. DNA2 can also be recruited stalled replication forks or DSBs to facilitate the repair of these intermediate structures via the HDR pathway.