Figure 3.

Genomic heterogeneity of mutations among multiple tumor sites. The columns represent specimen results from sequencing 13 specimens from 5 donors with a customized 567‐gene Agilent SureSelectXT panel. Each column represents one specimen with the top bar color representing which donor the specimen is from: 1 (black), 3 (red), 4 (green), 6 (dark blue), and 7 (light blue). For each gene on the left, there is an orange bar if a frame shift (FS) mutation, nonsense mutation, or splice variant is identified, a green bar if a missense mutation is identified, and a red bar if amplification is identified in that gene. If no colored bar is present (gray background), the specimen was negative for mutations in that gene. Abbreviations: FS, frameshift; purity, calculated tumor percentage; MutLoad, mutation load (number of mutations identified)