Table 3.

Multivariable Model of PICU Mortality in Pediatric Allogeneic HCT

	Odds Ratio	95% CI	p-value
Moderate/Severe Pre-HCT Renal Injury
None/mild	1.00
Moderate/severe	3.39	1.88–6.13	p<0.001
Recipient CMV Status
Negative	1.00
Positive	1.59	1.09–2.09	p=0.013
Unknown	1.39	0.87–2.21	p=0.166
Interval from HCT to PICU Admission
< 100 days	1.39	1.04–1.82	p=0.026
≥100 days	1.00
HCT Indication
ALL/Other acute leukemia	1.00
AML	1.94	1.24–3.05	p=0.004
CML/MDS/MPD	0.84	0.46–1.51	p=0.551
NHL/HL	0.97	0.47–2.03	p=0.942
Non-malignant disease	1.24	0.86–1.79	p=0.256
PRISM-3 Score (continuous*)	1.11	1.09–1.13	p<0.001

Footnotes: Generalized estimating equations (GEE) with clustering at the patient level were used to account for repeat PICU admissions of the same patient during the study interval.

^*Odds ratio for PRISM-3 score reflect increased mortality odds for each additional point of the score (range 0–47).