Table 3.
Change in geriatric assessment and global quality of life after induction (N=28)
| Measures | Baseline (mean±SD) |
Follow-up (mean±SD) |
Mean change from baseline±SD |
P-value |
|---|---|---|---|---|
| Activities of Daily Living (subscale of MOS Physical Health) | 69.5±27.8 | 60.5±26.6 | −9.0±33.3 | 0.13 |
| Instrumental Activities of Daily Living (subscale of the OARS) | 13.4±1.1 | 12.3±2.3 | −1.1±2.0 | 0.002 |
| *Karnofsky Self-Reported Performance Rating Scale | 81.9±15.9 | 82.6±17.9 | 0.7±21.3 | 0.66 |
| *Karnofsky Physician-Reported Performance Rating Scale | 82.8±13.1 | 84.8±9.6 | 2.0±13.2 | 0.52 |
| *No. of falls in last 6 months | 0.2±0.5 | 0.2±0.5 | 0±0.4 | 1.0 |
| *Timed Up and Go (seconds) | 13.5±4.3 | 12.1±3.9 | −1.4±3.7 | 0.06 |
| *Blessed Orientation Memory and Concentration Test (BOMC) | 4.0 ±3.2 | 3.2±4.2 | −0.6±3.6 | 0.18 |
| *Physician Health Section Survey (subscale of the OARS) | 3.4±3.5 | 3.7±4.6 | 0.3±5.0 | 0.80 |
| *HCT-CI | 1.9 (1.8) | 1.7 (1.6) | −0.2±1.2 | 0.51 |
| *Number of medications | 4.0±3.4 | 4.4±3.6 | 0.4±3.7 | 0.5 |
| Mental Health Inventory-17 | 56.1±3.4 | 54.2±3.2 | −1.9±4.3 | 0.04 |
| MOS Social Activity Survey | 62.3±22.1 | 42.4±23.1 | −19.9±24.7 | 0.0002 |
| MOS Social Support Survey: Emotional Information and Tangible Subscales | 94.3±10.5 | 91.7±15.2 | −2.4±13.5 | 0.63 |
| *Body Mass Index | 29.9±5.5 | 28.1±4.8 | −1.8±1.8 | <0.001 |
| *Percent unintentional weight loss in last 6 months | −2.7±12.5 | −8.2±13.4 | −5.6±17.3 | 0.03 |
| *EORTC QLQ C30 | 47.8±29.8 | 67.9±18.8 | 20.2±29.4 | 0.001 |
Abbreviations: MOS=Medical Outcomes Survey; OARS=Older American Resources and Services; HCT-CI=Hematopoietic cell transplantation comorbidity index; EORTC QLQ=European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C-30; QOL=quality of life, KPS=Karnofsky performance status
*
Represents score for number of subjects completing this assessment: Patient reported KPS, N=27; Physician KPS, N=25; number of falls, N = 25; Time up and go, N =23; Blessed Orientation Memory Concentration Test, N=23, physical health survey, N=27, HCT-CI, N=25, number of medications, N = 21; body mass index, N= 25, percent weight loss, N=24.