Fig. 2. Liver histopathology features of alcoholic hepatitis patients on Ayurvedic and herbal medications.

A. Extensive liver cell necrosis in a patient with severe alcoholic hepatitis associated with ballooned hepatocytes, Mallory-Denk bodies and mixed inflammatory reaction predominated with lymphocytes and eosinophils (hematoxylin and eosin, x40). B. Confluent necrosis in a patient with multiple unknown polyherbal Ayurvedic medications (hematoxylin and eosin, x100). C. Clusters of ballooned hepatocytes surrounded by submassive necrosis and pericellular fibrosis due to consumptions of multiple Ayurvedic products after diagnosis of alcoholic liver disease (Masson-trichrome stain, x100). D. Extensive ballooned hepatocytes with Mallory-Denk bodies, with hepatocellular and cholangiolar cholestasis associated with herbal drug intake (hematoxylin and eosin, x400). E. Mixed inflammatory cells of lymphocytes and eosinophils in the portal areas with surrounding ballooned hepatocytes in a patient with severe alcoholic hepatitis with herbal drug-induced liver injury (hematoxylin and eosin, x400). F. Severe canalicular cholestasis associated with liver cell necrosis and ballooning of hepatocytes seen in a patient consuming Ayurvedic supplements for alcoholic hepatitis (hematoxylin and eosin, x400). G. Extensive bridging necrosis associated with mixed cellular inflammation and pericellular fibrosis in a patient with severe alcoholic liver disease after consuming traditional Ayurvedic medicines (Masson trichrome stain, x100).