Table 3. Liver biopsy characteristics between groups.
Histology findings | AH–CAM group, n = 27 | Classical AH group, n = 29 | p value |
Steatosis | 100% | 100% | |
Grading of steatosis | Mild 48.1% | Mild 13.8% | 0.02 |
Moderate 44.4% | Moderate 65.5% | ||
Severe 7.4% | Severe 20.7% | ||
Predominant inflammation | Lymphocyte 63% | Lymphocytes 10.3% | <0.001 |
Neutrophils 37% | Neutrophils 89.7% | ||
Predominant site of inflammation | Lobular 0% | Lobular 75.9% | |
Portal 77.8% | Portal 0% | <0.001 | |
Lobular + portal 22.2% | Lobular + portal 24.1% | ||
Ballooning | 100% | 100% | |
Interface hepatitis | 70.4% | 0% | <0.001 |
Mallory Denk bodies | 77.8% | 100% | 0.007 |
Neutrophilic satellitosis | 29.6% | 55.2% | 0.05 |
Megamitochondria | 7.4% | 27.6% | 0.05 |
Pericellular fibrosis | 100% | 100% | |
Cirrhosis | 81.5% | 89.7% | 0.38 |
Plasma cells (portal, lobular or interface) | 37% | 6.9% | 0.006 |
Eosinophilic infiltration (portal, lobular or interface) | 44.4% | 0% | <0.001 |
Cholestasis | 74.1% | 20.7% | <0.001 |
Type of cholestasis | Hepatocellular 74.1% | Hepatocellular 20.7% | <0.001 |
Canalicular 40.7% | Canalicular 6.9% | 0.003 | |
Cholangiolar 44.4% | Cholangiolar 0% | <0.001 | |
Foamy degeneration | 40.7% | 17.2% | 0.05 |
Necrosis (any type) | 70.4% | 17.2% | <0.001 |
Patterns of necrosis | Periportal necrosis 25.9% | Periportal necrosis 0% | 0.004 |
Perivenular necrosis 22.2% | Perivenular necrosis 10.3% | 0.23 | |
Spotty necrosis 14.8% | Spotty necrosis 6.9% | 0.90 | |
Bridging necrosis 25.9% | Bridging necrosis 0% | 0.003 | |
Confluent necrosis 25.9% | Confluent necrosis 0% | 0.004 | |
Submassive necrosis 18.5% | Submassive necrosis 0% | 0.02 | |
Hepatocyte rossetting | 11.1% | 0% | 0.07 |
Sinusoidal dilatation | 33.3% | 0% | <0.001 |
Sinusoidal fibrosis | 44.4% | 7% | 0.001 |
Abbreviations: AH, alcoholic hepatitis; CAM, complementary and alternative medicine.