Table 4. Clinical characteristics of GCKR rs780094 T carriers and non-carriers in the study populationa.
| Characteristic | Controls | NAFLD | NAFLD + CAD | ||||||
| Carriers, n = 126 | Non-carriers,n = 26 | p value | Carriers, n = 117 | Non-carriers,n = 26 | p value | Carriers,n = 64 | Non-carriers,n = 18 | p value | |
| BMI (kg/m2) | 22.91 ± 4.36 | 24.44 ± 3.40 | 0.001 | 26.35 ± 3.50 | 27.05 ± 5.87 | 0.659# | 25.29 ± 2.422 | 25.05 ± 3.250 | 0.73# |
| FPG (mmol/L) | 4.45 ± 1.00 | 4.74 ± 1.00 | 0.043 | 4.74 ± 0.65 | 4.86 ± 0.60 | 0.405 | 5.18 ± 1.38 | 6.04 ± 3.16 | 0.001 |
| TC (mmol/L) | 5.04 ± 1.00 | 5.09 ± 2.00 | 0.860 | 5.49 ± 1.03 | 5.48 ± 1.28 | 0.947 | 4.52 ± 1.236# | 4.69 ± 1.430 | 0.616# |
| TG (mmol/L) | 1.08 ± 1.00 | 1.64 ± 2.00 | 0.002 | 1.53 ± 1.01 | 1.75 ± 1.19 | 0.252 | 1.49 ± 1.20 | 1.65 ± 1.33 | 0.751 |
| HDL (mmol/L) | 1.29 ± 0.00 | 1.15 ± 0.00 | 0.297 | 1.23 ± 0.27 | 1.23 ± 0.21 | 0.325 | 1.03 ± 0.33 | 1.06 ± 0.28 | 0.396 |
| LDL (mmol/L) | 3.07 ± 0.697 | 3.23 ± 0.754 | 0.295# | 3.25 ± 0.547 | 3.36 ± 0.586 | 0.349# | 2.74 ± 0.948 | 2.78 ± 1.083 | 0.866# |
| ALT (U/L) | 16.83 ± 11.00 | 19.29 ± 11.00 | 0.996 | 24.81 ± 23.66 | 21.77 ± 40.27 | 0.950 | 22.78 ± 18.59 | 20.41 ± 13.03 | 0.320 |
| AST (U/L) | 22.73 ± 6.00 | 20.33 ± 6.00 | 0.247 | 22.20 ± 8.50 | 20.38 ± 13.11 | 0.527 | 21.30 ± 18.61 | 20.34 ± 15.07 | 0.251 |
| r-GT (mmol/L) | 18.89 ± 13.00 | 22.02 ± 14.00 | 0.143 | 29.40 ± 26.76 | 37.35 ± 23.79 | 0.294 | 25.62 ± 16.73 | 23.19 ± 16.95 | 0.406 |
| ALP (mmol/L) | 69.92 ± 26.00 | 77.06 ± 36.00 | 0.417 | 66.87 ± 24.07 | 74.80 ± 22.73 | 0.056 | 79.85 ± 23.10 | 84.77 ± 28.11 | 0.809 |
| BIL (mmol/L) | 12.70 ± 6.00 | 11.50 ± 4.00 | 0.432 | 11.90 ± 5.10 | 12.30 ± 3.60 | 0.587 | 13.05 ± 6.15 | 12.65 ± 5.20 | 0.397 |
Abbreviations: NAFLD, patients with nonalcoholic fatty liver disease; NAFLD + CAD, patients with nonalcoholic fatty liver disease and coronary artery disease.
#
Values are expressed as mean ± SD and compared by Student’s t test.
a
Values are expressed as median ± quartile.