Skip to main content
. 2019 Dec 10;10(1):18–27. doi: 10.1002/2211-5463.12732

Figure 6.

Figure 6

DANCR positively regulates MMP16 expression by sponging miR‐33b. (A) The putative miR‐33b‐binding sequence of DANCR and MMP16. (B) Expression of MMP16 was measured in shDANCR or shNC‐transfected PANC‐1 and SW1990 cells. Data are expressed as mean ± SD, Student's t‐test. *P < 0.05. (C) Relative luciferase activity of HEK293T cells after cotransfection with either the MMP16‐Wt or MMP16‐Mt 3′UTR reporter gene along with either the shDANCR or shNC. Data are expressed as mean ± SD, Student's t‐test. *P < 0.05. (D) Expression of MMP16 in PANC‐1 and SW1990 cells transfected with shDANCR or cotransfected shDANCR and miR‐33b inhibitor. Data are expressed as mean ± SD, one‐way ANOVA. *P < 0.05 vs. control group; & P < 0.05 vs. shDANCR group.