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. 2019 Jun 6;69(1):18–31. doi: 10.1136/gutjnl-2018-318070

Figure 3.

Figure 3

The clonal and subclonal architecture inferred in peritoneal carcinomatosis (PC) specimens reflecting the complexity of intratumour heterogeneity. (A) Patterns of clonal and subclonal architecture inferred. Kernel density plots of variant allele frequency (VAF) across regions with copy number one, two, three or four, posterior predictive densities summed over all clusters for copy number neutral variants and posterior predictive densities for each cluster/component in 15 ascites samples with matched normal. (B) VAFs plotted vs read depth for each of the four copy number regions for three representative samples: IP-010–1, IP-022 and IP-031. Mutations in biologically important genes are labelled.