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. 2019 Oct 22;81(12):1868–1872. doi: 10.1292/jvms.19-0325

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©2019 The Japanese Society of Veterinary Science

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)

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Fig. 1. — Temporal changes in urinary liver-type fatty acid binding protein (L-FABP), serum creatinine (sCre), and blood urea nitrogen (BUN) before and after renal ischemia/reperfusion in feline acute kidney injury (AKI) models. A–C. Urinary L-FABP index. D–F. sCre (line) and BUN (dotted line) values. To generate AKI models in cats, vascular clamping of the bilateral renal arteries for 40 or 50 min was performed in two cats. The remaining (control) cat was subjected to a sham operation, in which only a midline laparotomy was performed for 50 min without vascular clamping. Urine and blood samples were collected daily, starting from 1 day before (day −1) till 7 days (day 1 to 7) after the treatment. A and D, B and E, and C and F show the results for the sham surgery cat, and the AKI model cat with 40 and 50 min of renal ischemia, respectively. Day 0 indicates the day of surgery. Pre, Rep, and Aft indicate sampling points on day 0 immediately before clamping, and 60 and 120 min after the renal reperfusion, respectively. POD denotes post-operative day. Urine samples of the sham surgery cat were collected at the same time points as that for the AKI model cats.