Table 2. Histopathological lung lesion scores at different intervals in group A and B mice after challenge with wild H3N8 equine influenza virus.
Days post challenge | Cellular infiltrations | Interstitial lesions | Necrotic changes | Total histopathological lesion | ||||
---|---|---|---|---|---|---|---|---|
Group A | Group B | Group A | Group B | Group A | Group B | Group A | Group B | |
1 | 1.17 ± 0.31c) | 2.33 ± 0.21 | 1 ± 0.25 | 1.83 ± 0.31 | 0.17 ± 0.17b) | 1.67 ± 0.42 | 1.33 ± 0.21c) | 2.33 ± 0.21 |
3 | 1.5 ± 0.34b) | 2.83 ± 0.31 | 1.5 ± 0.34a) | 3.17 ± 0.31 | 0.67 ± 0.49a) | 3 ± 0.26 | 1.5 ± 0.22a) | 3.17 ± 0.17 |
5 | 1.67 ± 0.22 | 2.67 ± 0.22 | 1.33 ± 0.21b) | 2.83 ± 0.17 | 0.67 ± 0.42 | 1.67 ± 0.56 | 1.67 ± 0.21a) | 3 ± 0.26 |
9 | 1.17 ± 0.31c) | 2.33 ± 0.21 | 1.17 ± 0.31c) | 2.5 ± 0.43 | 0.33 ± 0.21 | 1.17 ± 0.54 | 1.17 ± 0.17 | 2 ± 0.26 |
14 | 0.83 ± 0.17 | 1.83 ± 0.40 | 0.17 ± 0.17c) | 1.67 ± 0.49 | 0.17 ± 0.17 | 0.5 ± 0.34 | 0.5 ± 0.34 | 1.33 ± 0.42 |
28 | 0.83 ± 0.17 | 1 ± 0.37 | 0 ± 0 | 0.33 ± 0.21 | 0 ± 0 | 0 ± 0 | 0.17 ± 0.17 | 0.33 ± 0.21 |
Each value represents mean ± SEM (n=6). a) Indicates significant difference P<0.001, b) P<0.01, c) P<0.05, between groups in the same row in two way ANOVA, Bonnferoni post hoc test.