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TIGIT-expression on Treg cells has no significant suppressive capacity. (a) Expanded human Treg subsets co-cultured with CFSE-labeled CD25− T cell and OKT3 (30ng/ml) for 72 hours in the presence of irradiated APCs. The CFSE dilution was examined by flow cytometry and data is representative of 4 independent experiments. (b) Statistical summary of 4 RA patients. There were no significant differences in suppressive capacity between TIGIT+ Treg and TIGIT− Treg subsets (p>0.05).
