Figure 4.

SORBS2 inhibited liver metastasis. A total of 5 × 10⁵ SMMC-7721 or HCC-LM3 cells infected with an empty lentivirus (indicated as “Vector”) or SORBS2-expressing lentivirus were intrasplenically injected into nude mice. Three weeks later, the mice were euthanized for liver extraction. A. Representative livers after intrasplenic injection. B. Representative images of HE stained liver tissues after intrasplenic injection. Scale bar, 100 μm. C. Analysis of tumor numbers on the liver surface. *P < 0.05.