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. 2020 Jan;190(1):48–56. doi: 10.1016/j.ajpath.2019.09.010

Figure 1.

Figure 1

Kv11.1 channels are expressed in human lungs. Normal human lung hematoxylin and eosin (H&E) staining in a 41-year-old man (A) and 65-year-old woman (B). Shown are sections of the lung composed of terminal bronchiole (b) and thin-walled alveoli (a). Also shown is a thin layer of alveoli connective tissue and a multitude of pulmonary vessels (pv; arrows). C and D: Kv11.1 antibody staining of normal human lung in the 41-year-old man (C, right upper lobe) and 65-year-old woman (D, left lower lobe), with the structural elements denoted in the same manner as in A and B. E and F: Kv11.1 staining in bronchial smooth muscle layer (red arrows) and in the media of pulmonary arteries (PAs) of diameter >100 μm (black arrows) in the 41-year-old man (E) and 65-year-old woman (F). G and H: Arrows indicate the absence of Kv11.1 staining in small PAs (diameter <100 μm). I: Quantification of Kv11.1 channel expression [in arbitrary units (au)] in large and small PAs. J–M: Negative controls for E–H, correspondingly, with the primary antibody omitted and only the secondary antibody used. The mean of the data is indicated (red lines). n = 37 per group. *P < 0.05. Scale bars: 1 mm (A–D); 200 μm (E–H, J–M). Original magnification: ×16 (A–D); ×200 (E–H). IHC, immunohistochemistry.