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. 2020 Jan;190(1):48–56. doi: 10.1016/j.ajpath.2019.09.010

Figure 5.

Figure 5

Kv11.1 channel expression gradually increases with the development of pulmonary arterial hypertension (PAH) in rats. A: Time course examination of Kv11.1 expression in PAH rats (brown; arrows). For this experiment Fischer rats were injected with SU5416, placed in hypoxia for 3 weeks, and then maintained in normoxia for 2 weeks to obtain time points of 0, 1, 2, 3, 4, and 5 weeks after the SU5416 injection. B: Negative control for the corresponding images in A with the primary antibody omitted and only the secondary antibody used. C: Quantification of the changes in Kv11.1 channel expression [in arbitrary units (au)] with PAH development in small pulmonary arteries (PAs). The mean of the data is indicated (red lines). n = 10. *P < 0.05. Scale bars = 100 μm (A and B). Original magnification, ×400 (A). IHC, immunohistochemistry.