Table 1.
Inhibitory effects of synthetic compounds on the growth of different types of human cancer cells and normal mammary epithelial cells.
| Comp. | Antiproliferative Activity IC50 ± SEM (µM) | ||||||
|---|---|---|---|---|---|---|---|
| HeLa[a] | Hep G2[b] | MCF-7[c] | FaDu[d] | A549[e] | MCF 10A[f] | SI[g] | |
| 6a | >100 | >100 | >100 | >100 | >100 | 90.29 ± 3.41 | NCh |
| 6b | >100 | >100 | >100 | >100 | >100 | >100 | NCh |
| 6c | >100 | >100 | >100 | >100 | >100 | >100 | NCh |
| 6d | >100 | >100 | >100 | >100 | >100 | >100 | NCh |
| 6e | 62.67 ± 4.19 | 50.77 ± 1.35 | 66.36 ± 0.05 | 49.50 ± 1.61 | >100 | 85.44 ± 2.28 | 1.73 |
| 6f | 10.16 ± 0.55 | 10.72 ± 0.22 | 20.83 ± 0.14 | 10.94 ± 0.12 | 20.05 ± 0.41 | 12.97 ± 0.55 | 1.19 |
| 6g | 7.89 ± 0.86 | 9.62 ± 0.11 | 9.83 ± 0.17 | 6.80 ± 0.05 | 9.23 ± 0.16 | 6.57 ± 0.30 | 0.97 |
| 6h | >100 | >100 | >100 | >100 | >100 | >100 | NCh |
| 6i | >100 | >100 | >100 | >100 | >100 | >100 | NCh |
| 8a | >100 | >100 | >100 | >100 | >100 | >100 | NCh |
| 8b | >100 | >100 | >100 | >100 | >100 | >100 | NCh |
| 8c | >100 | >100 | >100 | 80.41 ± 1.36 | >100 | 46.59 ± 0.65 | NCh |
| 8d | 3.31 ± 0.14 | >20 | 0.480 ± 0.003 | 0.11 ± 0.03 | 6.35 ± 0.05 | 2.69 ± 0.46 | 24.45 |
| 8e | 1.42 ± 0.71 | >20 | 0.037 ± 0.001 | 0.00136 ± 0.00035 | 1.05 ± 0.05 | 0.047 ± 0.008 | 34.56 |
| 8f | 4.96 ± 1.62 | >20 | 0.158 ± 0.009 | 0.174 ± 0.010 | 2.46 ± 0.05 | 0.051 ± 0.021 | 0.29 |
| 9e | >100 | >100 | >100 | 0.054 ± 0.002 | 11.27 ± 0.81 | >100 | >1851.85 |
| 10e | >100 | >100 | >100 | 0.25 ± 0.02 | 2.94 ± 0.25 | 38.60 ± 2.48 | 154.40 |
| 11e | >100 | >100 | >100 | 0.50 ± 0.06 | 64.30 ± 3.46 | 80.54 ± 7.60 | 161.08 |
| 12e | >100 | >100 | >100 | 1.33 ± 0.07 | 8.77 ± 0.47 | >100 | >75.19 |
| 13e | >100 | >100 | >100 | 48.31 ± 3.17 | >100 | >100 | >2.07 |
| 14e | >100 | 97.75 ± 1.55 | >100 | 6.33 ± 0.65 | 44.37 ± 0.29 | 19.82 ± 1.41 | 3.13 |
| 15e | 37.74 ± 4.32 | 26.34 ± 5.36 | 21.48 ± 1.47 | 8.85 ± 0.45 | 23.08 ± 0.12 | 54.65 ± 5.92 | 6.18 |
| 16e | >100 | >100 | >100 | 88.11 ± 1.37 | >100 | >100 | NCh |
| 17e | >20 | >20 | >20 | 0.236 ± 0.005 | >20 | >20 | >84.75 |
| 18e | >20 | >20 | >20 | 0.697 ± 0.021 | >20 | >20 | >28.69 |
| 19e | >20 | >20 | >20 | 8.74 ± 0.44 | >20 | >20 | >2.29 |
| 20e | >20 | >20 | >20 | >20 | >20 | >20 | NCh |
| 21e | >20 | >20 | >20 | 0.665 ± 0.028 | >20 | >20 | >30.08 |
| 22e | >20 | >20 | >20 | 0.020 ± 0.002 | >20 | >20 | >1000 |
| 23e | >20 | >20 | >20 | 0.638 ± 0.089 | >20 | >20 | >31.35 |
| 24e | >20 | >20 | >20 | 5.296 ± 0.366 | >20 | >20 | >3.78 |
| 25e | >20 | >20 | >20 | 0.056 ± 0.016 | >20 | >20 | >357.14 |
| 26e | >20 | >20 | >20 | >20 | >20 | >20 | NCh |
| 27e | >20 | >20 | >20 | 4.621 ± 0.539 | >20 | >20 | >4.33 |
| 28e | >20 | >20 | >20 | >20 | >20 | >20 | NCh |
| 29e | >20 | >20 | >20 | 5.067 ± 0.461 | >20 | >20 | >3.95 |
| 30e | >20 | >20 | >20 | >20 | >20 | >20 | NCh |
| 31e | >20 | >20 | >20 | 5.594 ± 0.628 | >20 | >20 | >3.58 |
| 32e | >20 | >20 | >20 | >20 | >20 | >20 | NCh |
| 33e | >20 | >20 | >20 | 10.393 ± 0.949 | >20 | >20 | >1.92 |
| 34e | >20 | >20 | >20 | 5.853 ± 0.408 | >20 | >20 | >3.42 |
| 35e | >20 | >20 | >20 | >20 | >20 | >20 | NCh |
| 9d | >20 | >20 | >20 | 1.054 ± 0.091 | >20 | >20 | >18.98 |
| 9f | >20 | >20 | >20 | 0.027 ± 0.002 | >20 | >20 | >740.74 |
| 9g | >20 | >20 | >20 | >20 | >20 | >20 | NCh |
| 9h | >20 | >20 | >20 | >20 | >20 | >20 | NCh |
| 9i | >20 | >20 | >20 | >20 | >20 | >20 | NCh |
| 9j | >20 | >20 | >20 | >20 | >20 | >20 | NCh |
| 9k | >20 | >20 | >20 | 4.447 ± 0.208 | >20 | >20 | >4.50 |
| 9l | >20 | >20 | >20 | >20 | >20 | >20 | NCh |
| 9m | >20 | >20 | >20 | >20 | >20 | >20 | NCh |
| TMP | >100 | >100 | >100 | >100 | >100 | >100 | NCh |
| DOX | 11.39 ± 0.48 | 28.04 ± 1.09 | 6 ± 0.07 | 1.27 ± 0.13 | >100 | 0.55 ± 0.03 | 0.43 |
[a] HeLa (cervical cancer cell line); [b] Hep G2 (hepatocarcinoma cell line); [c] MCF-7 (breast cancer cell line); [d] FaDu (head and neck squamous carcinoma cell line); [e] A549 (epithelial cancer cell line); [f] MCF 10A (normal mammary epithelial cell); [g] SI: selectivity index. It was calculated as: SI = IC50 (MCF 10A)/IC50 (FaDu); [h] NC: not calculated.