Table 1.
Effect of formulation parameters on physicochemical characteristics of gemcitabine-loaded galactosylated chitosan nanoparticles.
| F | Drug: Polymer Ratio | % Yield | % EE | % Drug Loading | % Drug Content | Mean Diameter (nm) | Zeta Potential (mV) |
|---|---|---|---|---|---|---|---|
| G1 | 1:2 | 68.5 ± 6.1 | 54.6 ± 3.2 | 18.2 ± 2.9 | 93.5 ± 2.5 | 156.8 ± 30.1 | 19.3 ± 2.6 |
| G2 | 1:4 | 72.5 ± 7.8 | 64.2 ± 5.9 | 12.8 ± 1.6 | 94.1 ± 2.1 | 157.2 ± 38.3 | 21.5 ± 3.1 |
| G3 | 1:6 | 73.4 ± 5.9 | 66.4 ± 6.1 | 9.5 ± 2.1 | 94.6 ± 2.8 | 162.0 ± 34.2 | 22.3 ± 2.5 |
| G4 | 1:8 | 74.2 ± 7.4 | 72.1 ± 6.5 | 8.0 ± 2.3 | 95.9 ± 3.2 | 164.1 ± 39.5 | 20.4 ± 3.9 |
| G5 | 1:10 | 73.2 ± 6.5 | 71.9 ± 4.2 | 6.5 ± 2.2 | 94.4 ± 2.8 | 171.3 ± 35.2 | 21.8 ± 2.1 |
All values are expressed as mean ± S.D; n = 6. F: Formulation; EE: Entrapment efficiency.