Table 2.
Effect of irisin on different types of adipocytes
| Subcutaneous | Visceral | Brown | |
|---|---|---|---|
| Expression of browning gene | Increase | No effect | No effect |
| Thermogenesis | Increase | Increase | Increase |
| Adipogenic differentiation | Inhibit | Inhibit | ND |
| Osteogenic differentiation | Promote | Promote | ND |
| Activation of p38/ERK signaling pathway | Yes | No | No |
| Inflammatory cytokines | Decrease pro-inflammation cytokines expression; Increase anti-inflammatory cytokines expression | Decrease pro-inflammation cytokines expression; Increase anti-inflammatory cytokines expression | ND |
Abbreviations: ND, not done.