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The multiple functions of ITGB3 in tumor immune microenvironment. In solid tumor, the enhanced ITGB3 signaling facilitates an immunosuppressive environment by recruiting M2 type macrophages and neutrophils, and making CD8+ T cells inactivation. While in hematological tumor, ITGB3 promotes NK cell and Th1 cell activation, thus amplifies the anti-tumor effects.
