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The regulation network of ITGB3 in tumor cells. TGF-β is the main up-stream of ITGB3, other upstream modulators like MEGF8, HOXD3 and several mi-RNAs have been confirmed to regulate ITGB3 expression. The classical downstream signaling of ITGB3 including FAK/PI3K/AKT, MEK/ERK, Akt, YAP/TAZ, KRAS/RalB/NF-κb, etc.
