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. 2019 Dec 15;11(12):7255–7271.

Figure 6.

Figure 6

BEZ235 significantly enhanced the anti-tumor effect of paclitaxel in vivo by PI3K/mTOR double inhibition. A. tumor tissues of each group (control group: 100 μl saline daily, ip; PTX group: 10 mg/kg weekly, ip; BEZ235 group: 45 mg/kg daily, oral treatment; BEZ235-PTX group: PTX: 10 mg/kg weekly, ip and BEZ235: 45 mg/kg daily, oral treatment) were isolated and collected after 28-day-treatment of tumor-bearing mice. Tumor volume expressed as mean ± SD. n=5. B. Partial tumor tissue was lysed to extract tissue protein for WB analysis. C. Each treatment groups IHC analysis results of Ki-67 and GPC3. Data expressed as mean ± SD, n=3 (*P<0.05; **P<0.01; ***P<0.001).