Table 5.
Correlation between TREM-1 with DAP-12, TLR2, TLR4, HMGB-1 and RAGE in omentum, subcutaneous and liver tissues of study subjects
| Target genes correlation | Obese non-diabetics (OND) | Obese diabetics (OD) | Correlation (R); P value |
|---|---|---|---|
| Increased TREM-1 (OND-21/23; OD-18/18) association with other genes in omentum biopsy samples | |||
| DAP-12 | 19/21 (90.5%) | 18/18 (100%) | NS |
| HMGB1 | 17/21(81.0%) | 18/18 (100%) | NS |
| RAGE | 15/21 (71.4%) | 18/18 (100%) | NS |
| TLR-4 | 21/21 (100%) | 18/18 (100%) | NS |
| TLR-2 | 19/21 (90.5%) | 18/18 (100%) | NS |
| Increased TREM-1 (OND-13/23; OD-13/18) association with other genes in subcutaneous biopsy samples | |||
| DAP-12 | 9/13 (69.2%) | 13/13 (100%)* | R = 0.426; P = 0.048 |
| HMGB1 | 9/13 (69.2%) | 12/13 (92.3%) | NS |
| RAGE | 8/13 (61.5%) | 9/13 (69.2%) | NS |
| TLR-4 | 13/13 (100%) | 13/13 (100%) | NS |
| TLR-2 | 9/13 (69.2%) | 12/13 (92.3%) | NS |
| Increased TREM-1 (OND-12/23; OD-18/18) association with other genes in liver samples | |||
| DAP-12 | 12/12 (100%) | 18/18 (100%) | NS |
| HMGB1 | 7/12 (58.3%) | 18/18 (100%)** | R = 0.548; P = 0.006 |
| RAGE | 5/12 (41.7%) | 13/18 (72.2%)* | R = 0.356; P = 0.045 |
| TLR-4 | 7/12 (58.3%) | 18/18 (100% )** | R = 0.548; P = 0.006 |
| TLR-2 | 6/12 (50%) | 18/18 (100%)*** | R = 0.612; P = 0.002 |
Subject’s categorical variables with correlation between TREM-1 and DAP-12, TLR2, TLR4, HMGB-1 and RAGE were analyzed among obese non-diabetics and obese diabetics using Fisher’s exact test or Pearson’s χ2 test. Data show number of subjects having higher values of these compared to control non-obese subjects. Values show number of subjects (% subjects of total), not significant (NS).
*
P < 0.05;
**
P < 0.01;
***
P < 0.001.