Western blotting analysis was used to detect the protein expression of HMGB1, GSDMD, IL-1β and IL-18 in HUVECs. Subablative treatment significantly increased the expressions of HMGB1, cleaved GSDMD, IL-1β and IL-18 protein, and EP efficiently decreased HMGB1, cleaved GSDMD, IL-1, and IL-18 expressions. *P < 0.05, **P < 0.01.