Table 1.
Comparison of clinical parameters between SIRS and Non-SIRS group patients after RF ablation for hepatice hemangiomas
| Non-SIRS group (n = 47) | SIRS group (n = 29) | P value | |
|---|---|---|---|
| Age (y) | 52.04 ± 8.46 | 48.72 ± 13.75 | 0.834 |
| Sex | 0.721 | ||
| Female | 19 (40.43%) | 15 (51.72%) | |
| Male | 28 (59.57%) | 14 (48.28%) | |
| Concomitant illness | |||
| Gallbladder stones | 8 (17.02%) | 5 (17.24%) | 0.674 |
| Type 2 diabetes mellitus | 9 (19.15%) | 4 (13.79%) | 0.579 |
| History of open cholecystectomy | 3 (6.38%) | 2 (6.90%) | 0.756 |
| Chronic hepatitis B | 3 (6.38%) | 2 (6.90%) | 0.632 |
| Hepatic cysts | 6 (12.77%) | 7 (24.13%) | 0.243 |
| History of previous liver surgery | 2 (4.26%) | 1 (3.43%) | 0.768 |
| Volume of hemangiomas (cm3) | 96.75 ± 36.90 | 258.92 ± 167.781 | 0.032 |
| Distribution of lesion, N (%) | 0.598 | ||
| Right lobe | 21 (44.68%) | 14 (48.28%) | |
| Left lobe | 26 (55.32%) | 15 (51.72%) | |
| Approach of RF ablation, N (%) | 0.607 | ||
| Laparoscopic approach | 36 (76.60%) | 24 (82.76%) | |
| Percutaneous approach | 11 (23.40%) | 5 (17.24%) | |
| Time of ablation (min) | 29.59 ± 7.21 | 48.32 ± 13.65 | 0.031 |
| Laboratory findings-pre | |||
| ALT (U/L) | 20.32 ± 11.43 | 23.38 ± 13.61 | 0.847 |
| AST (U/L) | 22.38 ± 6.86 | 21.42 ± 8.47 | 0.649 |
| Total bilirubin (μmol/L) | 13.87 ± 4.23 | 12.55 ± 3.65 | 0.246 |
| BUN (mmol/L) | 4.25 ± 1.43 | 3.64 ± 0.96 | 0.578 |
| Creatinine (μmol/L) | 60.32 ± 12.45 | 59.11 ± 13.25 | 0.467 |
| CRP (mg/L) | 4.24 ± 0.45 | 5.75 ± 6.56 | 0.368 |
| Laboratory findings-post 1 hour | |||
| ALT (U/L) | 74.56 ± 23.34 | 88.56 ± 20.46 | 0.039 |
| AST (U/L) | 118.45 ± 68.46 | 205.67 ± 70.53 | 0.023 |
| Total bilirubin (μmol/L) | 23.54 ± 6.34 | 38.56 ± 13.67 | 0.016 |
| BUN (mmol/L) | 3.34 ± 0.94 | 5.85 ± 1.43 | 0.045 |
| Creatinine (μmol/L) | 60.11 ± 13.43 | 78.44 ± 12.54 | 0.046 |
| CRP (mg/L) | 5.01 ± 0.63 | 7.01 ± 2.01 | 0.032 |
| Pyroptosis-related index-post 1 hour | |||
| HMGB-1 (pg/ml) | 505.08 ± 85.86 | 1027.58 ± 147.55 | 0.003 |
| IL-1β (pg/ml) | 2.95 ± 0.61 | 9.81 ± 1.03 | 0.014 |
| IL-18 (pg/ml) | 50.39 ± 12.58 | 149.44 ± 14.56 | 0.004 |
| LDH (U/L) | 250.78 ± 101.46 | 708.29 ± 113.57 | 0.012 |
SIRS, systemic inflammatory response syndrome; RF, radiofrequency; ALT, alanine aminotransferase; AST, aspartate transaminase, BUN, blood urea nitrogen; CRP, C-reactive protein; IL-1β, interleukin-1β; IL-18, interleukin-18; LDH, lactate dehydrogenase.