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. 2019 Dec 11;8(12):636. doi: 10.3390/antiox8120636

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Histological features of the liver in the experimental groups: (A) Control group—a normal histological aspect of the liver, H&E stain. (B) Fructose group—diffuse degenerative changes represented by a vacuolated aspect of the hepatocytes (black arrow) with karyopyknosis and nuclear fading (blank arrow), H&E stain. (C) Fructose group—intrahepatocytic vacuoles display a PAS-positive material suggesting glycogen accumulation (black arrow), PAS stain. (D) Fructose-fed group treated with alpha-lipoic acid (F + AL group)—perilobular location of the multivacuolated hepatocytes (black arrow), with no significant changes of the hepatocytes from the centrilobular and mediolobular zones (blank arrows).