Table A2.
Effect of rosmarinic acid and sinapic acid on the biochemical parameters in the serum of HFD + STZ-induced type 2 diabetic rats.
| Parameter | C | DM2 | RA10 | RA50 | SA5 | SA25 |
|---|---|---|---|---|---|---|
| Estradiol (pg/mL) | 43.84 ± 10.84 | 22.41 ± 2.03 | 18.64 ± 1.92 | 31.49 ± 5.07 | 21.67 ± 5.34 | 34.58±8.29 |
| Interleukin-18 (pg/mL) | 348.8 ± 21.8 a | 141.9 ± 8.8 b | 190.2 ± 26.5 b | 149.4 ± 15.1 b | 198.0 ± 30.2 b | 172.1 ± 7.1 b |
| AST (U/L) | 36.54 ± 3.54 | 33.25 ± 4.92 | 31.27 ± 2.91 | 36.70 ± 5.80 | 38.11 ± 3.81 | 37.36 ± 3.52 |
| ALT (U/L) | 5.53 ± 0.64 c | 11.81 ± 1.26 a,b | 11.97 ± 2.23 a,b | 10.05 ± 1.14 b | 16.61 ± 2.80 a | 13.32 ± 1.54 a,b |
| Uric acid (mg/dL) | 1.05 ± 0.06 | 2.11 ± 0.40 | 2.74 ± 0.59 | 2.27 ± 0.89 | 2.88 ± 0.73 | 1.29 ± 0.19 |
| Urea (mg/dL) | 38.87 ± 2.02 a | 29.79 ± 1.83 b | 29.87 ± 3.19 b | 32.60 ± 3.55 a,b | 33.50 ± 3.53 a,b | 26.58 ± 2.29 b |
| Creatinine (mg/dL) | 0.466 ± 0.017 | 0.445 ± 0.010 | 0.469 ± 0.038 | 0.446 ± 0.018 | 0.413 ± 0.012 | 0.441 ± 0.006 |
The results presented as mean ± SEM were evaluated by one-way ANOVA followed by LSD post-hoc test (statistically significant if p < 0.05). Values which have the same superscript letter(s) within each row are not significantly different. When no letters are present in the superscript, the ANOVA test was not significant. C: control rats; DM2: HFD + STZ-induced diabetic rats; RA10 and RA50: HFD + STZ-induced diabetic rats treated with rosmarinic acid at a dose of 10 mg/kg and 50 mg/kg, respectively; SA5 and SA25: HFD + STZ-induced diabetic rats treated with sinapic acid at a dose of 5 mg/kg and 25 mg/kg, respectively, for 28 days; AST: aspartate aminotransferase; ALT: alanine aminotransferase.