Figure 6.

A schematic presentation of the experimental protocols. Mice were divided into a non-stress group and the chronic mild stress (UCMS) group at week 0. The UCMS group was exposed to various unpredictable, stressful stimuli from week 0 to week 6. The UCMS group was divided into four groups which were daily administered with (i) vehicle, (ii) vitamin E (100 mg/kg, p.o.), (iii) KBD (100 mg/kg, p.o), and (iv) KBD (500 mg/kg, p.o) for 3 weeks after day 21. Y-maze test and NORT were conducted at week 5 to week 6. Twenty-four hours after the behavioral test, the animals were decapitated to collect the blood and brain for neurochemical assessment.