Table 2.
Association between plasma IL-6 concentration and CRC risk stratified by anatomic site.
| Plasma IL-6 Concentration (pg/mL) | |||||
|---|---|---|---|---|---|
| Q1 (<0.98) | Q2 (0.98 to <1.36) | Q3 (1.36 to <2.04) | Q4 (≥2.04) | P for Trend | |
| Colorectal cancer | |||||
| No. controls/cases | 328/52 | 328/94 | 328/154 | 328/354 | |
| Crude OR (95% CI) | 1.0 (ref) | 1.81 (1.25–2.62) | 2.96 (2.09–4.20) | 6.81 (4.90–9.46) | <0.001 |
| Multivariable OR (95% CI) a | 1.0 (ref) | 1.97 (1.24–3.11) | 2.82 (1.82–4.37) | 6.23 (4.10–9.45) | <0.001 |
| Colon cancer | |||||
| No. controls/cases | 328/32 | 328/46 | 328/80 | 328/176 | |
| Crude OR (95% CI) | 1.0 (ref) | 1.44 (0.89–2.31) | 2.50 (1.61–3.87) | 5.50 (3.66–8.26) | <0.001 |
| Multivariable OR (95% CI) a | 1.0 (ref) | 1.63 (0.94–2.84) | 2.33 (1.39–3.92) | 4.77 (2.93–7.76) | <0.001 |
| Rectal cancer | |||||
| No. controls/cases | 328/20 | 328/48 | 328/72 | 328/168 | |
| Crude OR (95% CI) | 1.0 (ref) | 2.40 (1.39–4.13) | 3.60 (2.14–6.05) | 8.40 (5.16–13.69) | <0.001 |
| Multivariable OR (95% CI) a | 1.0 (ref) | 2.42 (1.29–4.55) | 3.48 (1.90–6.39) | 8.06 (4.52–14.39) | <0.001 |
Q, quartile. REF: Reference. a Multivariable odds ratio (OR) was adjusted for age, sex, BMI, education level, occupation, income, smoking status, alcohol consumption, physical activity, first-degree family history of CRC, and total energy intake. Significant p-values that met the 5% level.