Figure 2.

Testing visits schedule. Participant compliance was controlled at the beginning of each testing visit. After evaluation of cardiovascular parameters and blood sampling, they were served with a standardised breakfast and exposed to the cognitive demand battery (CDB) twice for practice before treatment intake. After a 90 min at rest (absorption period), subjects were transferred in a dedicated room for 66 min of intensive cognitive challenge comprising 6 consecutive CDB repetitions in order to test attention and working memory through a serial three subtraction task (STS), a serial seven subtraction task (SSS), a rapid visual information processing task (RVIP), and subjective ratings using visual analogical scales (VAS). After a second set of cardiovascular measures and blood sampling, subject was having a snack before terminating the visit.