Figure 3.

The redox status of patients with rheumatoid arthritis in (a): Methotrexate (MTX) and (b): “MTX + ozone” groups at the end of the study. (A) Protective redox markers, (B) Injury redox markers. The units of each marker are: SOD (superoxide dismutase, U/mL/min) and CAT (catalase, U/L/min) activities, GSH (reduced glutathione, µM), NO (nitric oxide, µM), AOPP (advanced oxidation protein products, µM), TH (total hydroperoxides, µM), MDA (malondialdehyde, µM). Data represent the mean ± S.E.M. of each group. Data analysis for each group was made by t-test. All differences between MTX vs. MTX + ozone groups were statistically significant, p < 0.05. From Ref. [56], with permission.