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A comparison of the antinociceptive effect of single (Day 1) and repeated (Day 7) i.p. injections of opioid analog 1 and hybrids 2 and 4 at the dose of 5 mg/kg in the writhing test in mice. The data represent mean ± SEM, n = 10. Statistical significance was assessed using one-way ANOVA and a post hoc multiple comparison by the Student–Newman–Keuls test. *** p < 0.001, as compared to control.
