FIGURE 5.

S1P lyase inhibition did not alter de novo T-cell recruitment to the intestine. A, B, Effect of DOP on the frequency of total CFSE-labeled T cells migrating to the thymus, spleen, MLNs, and ileal LP of recipient TNFΔARE mice. C, Effect of DOP on the frequency of CFSE-labeled CD4+ and CD8+ T cells migrating to the spleen, MLNs, and ileal LP. D, Analyses of naïve, effector, and central memory subsets within the CD4 and CD8+ T cells migrating to indicated sites. Data are from 3 independent experiments expressed as mean ± SEM; n ≥ 10 mice/group (*P < 0.05, ^**P < 0.01, ^***P < 0.001 by 2-tailed t test).