Table 2.

Acetylcholinesterase (AChE) inhibition of alkaloids in STR and CR.

Name	IC50	AChE Inhibitory Activity 1
STR extract	570.11 ± 10.41 μg/mL	+
CR extract	4.11 ± 0.15 μg/mL	+++
PCC extract	22.19 ± 3.12 μg/mL	++
Fangchinoline	2.17 ± 0.05 μM	+++
Tetrandrine	−	−
Coptisine	13.50 ± 1.48 μM	+
Berberine	2.33 ± 0.16 μM	+++
Palmatine	6.52 ± 0.84 μM	++
Epiberberine	18.70 ± 0.83 μM	+
Tacrine 2	0.44 ± 0.12 μM	+++

AChE inhibitory activity ¹: “+” to “+++” indicate the ranking of AChE inhibitory activity; for molar concentration, “+++”, “++”, and “+” represent IC₅₀ values of 1–5, 5–10 and 10–20 μM, respectively; for mass concentration, “+++”, “++”, and “+” represent IC₅₀ values of 1–10, 10–100 and 100–600 μg/mL respectively; “−” indicates no effect. Tacrine ²: TAC served as a positive control. Data was expressed as Mean ± SEM, n = 3, each with triplicate samples.