Figure 1.

Overview of the representative brain projects

Numbers in cycles indicate the number of brain samples used in each project. Different data types are indicated using different colors, which include genotype, RNA expression, DNA methylation, and histone modification data. Colors in the bottom panel indicate the distribution of healthy controls or patients with different diseases included in the respective projects. The projects and their web links for access were listed below. BrainCloud (http://braincloud.jhmi.edu/) [35]; BrainSpan (http://www.brainspan.org/) [27], [28]; UKBEC, UK Brain Expression Consortium (www.braineac.org/) [29]; GTEx, Genotype Tissue Expression Project (https://gtexportal.org/) [30]; CMC, CommonMind Consortium (commonmind.org/) [31]; BrainSeq (http://eqtl.brainseq.org/) [32]; ROSMAP, the Religious Orders Study and Memory and Aging Project (http://www.radc.rush.edu/) [33]. Only Capstone 1 data from PsychENCODE (http://www.psychencode.org/) were summarized in this figure. PsychENCODE Capstone 1 data comprise BrainGVEX, BrainSpan, CommonMind, UCLA- ASD, Yale- ASD, BipSeq, LIBD szControl, and CMC_HBCC datasets, but does not include fetal brain samples and outliers. CTL, control; SCZ, schizophrenia; MDD, major depressive disorder; BIP, bipolar disorder; AD, Alzheimer’s disease; ASD, autism spectrum disorder.