Fig. 4.

Schematic diagram illustrating the dual roles of the LTBP family in TGFβ regulation and matrix assembly. Shown on the left, LTBP1, -3 and -4 form a large latent TGFβ complex which binds fibrillin to sequester TGFβ in the matrix. In TGFβ-independent mechanisms, shown on the right, LTBP1 can multimerize which is enhanced by HS (potentially on syndecans) and stabilised by TG2 cross-linking, LTBP2 stabilises fibrillin bundles and LTBP4 binds fibulin-4 and -5 to aid in deposition of elastin aggregates on fibrillin microfibrils in elastogenesis.