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. Author manuscript; available in PMC: 2020 Dec 18.
Published in final edited form as: Cell Syst. 2019 Nov 27;9(6):559–568.e4. doi: 10.1016/j.cels.2019.10.007

Figure 3. Network analysis of disease associated genes,

Figure 3.

a, disease associated genes are retrieved from DisGeNET database or independently from particular GWAS studies, and brain-related disorders are classified in 3 disease classes: psychiatric, neoplastic, and neurodegenerative. b, An interaction overlap test is performed to test whether interactions reported in PCNet and connecting genes from the same disease class are overrepresented within the interactions predicted by SCINET to occur in a given cell-type, c, For each individual disease, a network localization test is performed to quantify the degree to which disease genes form compact modules within a given cell-type specific interactome network. See also Figure S5.