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. Author manuscript; available in PMC: 2020 Jan 6.
Published in final edited form as: Integr Biol (Camb). 2013 Jan;5(1):29–42. doi: 10.1039/c2ib20047c

Figure 5. MMP-targeting f-NPs inhibit the tumorigenesis in the blood transfer model of MDA-MB-231-luc cancer mice.

Figure 5.

A) 1×10^6 MDA-MB-231-luc cells were injected into the tail vein of the nude mice. Seven days after injection, the mice received daily intraperitoneal doses of the f-NPs at 2.5 μmol/kg for a duration of 6 weeks. Saline was used as control. Tumor metastases in lung were monitored weekly by bioluminescence imaging (BLI). B) Quantification of the BLI intensity of tumor foci in the lungs of animals after different treatments. f-NPs treatment significantly inhibited tumor metastasis. *P < 0.05, compared to control. Reproduced from Meng et al.72